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In today’s fast-paced world, many people are looking for new ways to clear their minds, feel more present, and improve their mental health. One method gaining popularity is microdosing, which isn’t just for those interested in psychedelics anymore. As people seek alternative approaches to managing stress, improving mental health, and enhancing productivity, microdosing emerges as a promising tool for modern-day issues. With so much information available it’s easy to get stuck and confused. That’s why we will try to explain how to microdose safely and incorporate it into your mental health practice.

How to Microdose Safely

Microdosing goes beyond just seeking benefits. It’s about going on a mindful journey, guided by knowledge and respect for these powerful substances. Here are some safety precautions to follow:


microdosing capsules, powder and mushrooms on pastel background depicting the question on how to microdose safely


Choosing the Right Microdosing Protocols

As microdosing is gaining more attention as a potential way to improve mental health without experiencing full psychedelic effects, many different microdosing protocols have been developed. However, finding the right protocol can be exhausting. The goal should be finding the optimal regimen that provides desired benefits while minimizing risks or unwanted experiences. With the right approach, microdosing may be a promising practice for improving mental health. If you want to learn how to microdose safely, follow some of these regimens:

Fadimans Protocol

Dr. James Fadiman established the first standardized method of microdosing with the Fadiman Protocol. This carefully thought-out approach is generally seen as low-risk and safe, providing people with a handy means of experimenting with microdosing. Numerous individuals have mentioned feeling less depressed and anxious and having increased creativity, attention, and concentration. Some have even reported gains in social relations and emotional control. This protocol is ideal for those who are new and want to try microdosing to improve mental health.

For a period of four to eight weeks, the Fadiman Protocol suggests taking one dosage every three days, separated by two days off. This regimen guarantees the substance’s full metabolic processing and aids in avoiding any possible buildup in the body that can result in tolerance. It is recommended that the dosage be taken in the morning.


fadiman protocol chart


Stamets Protocol (Stamets Stack)

In the mushroom world, Paul Stamets is an important figure, and his microdosing regimen, sometimes called the “Stamets Stack,” has garnered a lot of interest. This treatment includes tiny dosages of niacin (vitamin B3), psilocybin, and a functional mushroom called lion’s mane. This mixture is intended to stimulate the healing of pre-existing neurological damage, promote the formation of new brain connections, and improve cognitive performance.

The idea behind Stamets Stack is that these substances complement one another. Niacin, for example, has been shown to increase blood flow and decrease anxiety, and lion’s mane is thought to improve cognitive performance and encourage neuron regeneration. The theory behind this is that by working together, these effects enhance psilocybin’s processing and absorption, optimizing its potential for mental health.


stamets protocol chart


Nightcap Protocol

When microdosing, dosages are usually taken in the morning and their effects are monitored throughout the day. However, the Nightcap Protocol offers a different approach, catering to those aiming to improve the quality of their sleep. Mental health conditions like anxiety can make falling asleep much harder, and this protocol may help people overcome this problem.
With the Nightcap Protocol, people should take their microdose every other night before bedtime. It is advised to take the medicine at least one hour before going to bed. This timing allows the effects to unfold during the sleep cycle, potentially facilitating deeper and more restorative rest.


nightcap protocol chart


Intuitive Microdosing

Microdosing is a very flexible practice that allows people to customize the protocol to suit their own requirements and intuition. Users can participate in the practice in a way that meets their preferences by customizing their microdosing regimen. Unlike traditional microdosing protocols, there’s no rigid timetable to adhere to for specific dosing routines. Instead, users have the flexibility to choose the timing that feels right for them, based on their body’s intuition.

Intuitive microdosing is suitable for people who have gained some expertise with microdosing and have completed a few cycles using traditional protocols. The flexibility of this your own protocol makes it possible to combine psilocybin with other substances like vitamins, herbs, cacao, and functional mushrooms. However, it’s important to avoid combining psilocybin with plants containing MAOIs, as they can amplify the effects, turning a microdosing into a psychedelic experience. Some examples of these herbs include Syrian rue, Passionflower, Nutmeg, Licorice, and Banisteriopsis caapi (Ayahuasca vine).

How to Start With Microdosing

Now you know how to microdose safely, make sure to follow us to learn more. If you’re looking to dip your toes into the world of microdosing but aren’t sure where to begin, you’re in the right place. At MamaDose, we understand that starting with microdosing can feel like stepping into uncharted territory. That’s why we’ve curated a comprehensive 30-day microdosing course designed to guide you through this transformative journey and test microdosing.
Our course provides you with the tools and knowledge needed to explore microdosing safely and effectively, allowing you to unlock its full potential. With premium quality products and expert guidance, MamaDose is a go-to for many microdosers in the US.

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